Dr. Frenkel's research focuses on practical questions related to the prevention of HIV-1 infection in infants, mechanisms leading to shedding of virus in adults and treatment of drug-resistant virus in children and adults. Several od her lab's projects evaluate the selection and dynamics of drug-resistant HIV-1 mutants during antiretroviral therapy (ART) and as a result of peripartum chemoprophylaxis given to women and infants.
Dr. Frenkel is also keenly interested in the implementation of interventions to prevent mother-to-child-transmission in resource-strapped communities, and understanding the mechanisms that cause some adults but not others to shed HIV-1 from their, in their breast milk or from their genital tract. In addition, we aim to develop and transfer practical and economical assays for HIV-1 detection in infants, and for monitoring treatment and drug-resistant mutants in these communities.
Her projects include collaborative studies with colleagues in India, Kenya, Mozambique, Peru, Thailand, the USA and Zimbabwe.