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TREE has been engaged in medical research in Kenya for nearly two decades. A primary focus of its research has been on HIV-infected individuals and how to improve their care and treatment in this resource-limited setting. It has implemented several significant randomized clinical trials that have influenced national and international medical practice on topics as diverse as perinatal breast milk transmission of HIV, adherence to antiretroviral medications, and treatment of cervical pre-cancerous lesions among HIV-infected women. As a result, it has a robust technical and administrative infrastructure to engage in cutting-edge research and implement successful clinicals trials in Kenya and East Africa.

Currently, TREE is engaged in four major research areas: first, it is examining chronic lung disease among HIV-infected children and adolescents; second, it is determining the best methods to screen and treat HIV-infected women for cervical cancer; third, it is analyzing cardiac biomarkers among HIV adults; and fourth, it is studying the use of an oligonucleotide ligation assay (OLA) to detect pre-treatment antiretroviral drug resistance. 

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